6PPD-Q

• Description:

  6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders[1].

• Product Name Alternative:

  6PPD-Quinone

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  α-synuclein

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/6ppd-q.html

• Purity:

  99.30

• Solubility:

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1C(NC(C)CC(C)C)=CC(C(NC2=CC=CC=C2)=C1)=O

• Molecular Formula:

  C18H22N2O2

• Molecular Weight:

  298.38

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Du B, et al. First report on the occurrence of N- (1, 3-dimethylbutyl) -N’-phenyl-p-phenylenediamine (6PPD) and 6PPD-quinone as pervasive pollutants in human urine from south China. Environ Sci Technol Lett, 2022, 9 (12) : 1056-1062.|[2]Fang J, et al. 6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding. J Hazard Mater. 2024 Mar 5;465:133312.|[3]Yang Y, et al. Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation[J]. Science of The Total Environment, 2024, 918: 170679.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  α-synuclein Aggregation

• CAS Number:

  2754428-18-5