6PPD-Q

CAT: 0804-HY-153169-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-153169-01Size:5 mg
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Description
6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders[1].
CAS Number
[2754428-18-5]
Product Name Alternative
6PPD-Quinone
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/6ppd-q.html
Purity
99.30
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(NC(C)CC(C)C)=CC(C(NC2=CC=CC=C2)=C1)=O
Molecular Formula
C18H22N2O2
Molecular Weight
298.38
Precautions
H302, H315, H319
References & Citations
[1]Du B, et al. First report on the occurrence of N- (1, 3-dimethylbutyl) -N’-phenyl-p-phenylenediamine (6PPD) and 6PPD-quinone as pervasive pollutants in human urine from south China. Environ Sci Technol Lett, 2022, 9 (12) : 1056-1062.|[2]Fang J, et al. 6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding. J Hazard Mater. 2024 Mar 5;465:133312.|[3]Yang Y, et al. Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation[J]. Science of The Total Environment, 2024, 918: 170679.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

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