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G12Si-2

CAT: 0804-HY-150927Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150927Size:1 Each
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Description
G12Si-2, an analog of G12Si-1 , is a negative control tool. G12Si-2 is not a covalent inhibitor of the G12S mutant of K-Ras[1].
CAS Number
2946593-43-5
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/g12si-2.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC2=CC=CC(N3CC4=C(CC3)C(N5CC6C(CC5)OC6=O)=NC(OC[C@@H]7CCCN7C)=N4)=C21
Molecular Formula
C29H32ClN5O3
Molecular Weight
534.05
References & Citations
[1]Ziyang Zhang, et al. Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras (G12S) . Nat Chem Biol. 2022 Jul 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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