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G12Si-5

CAT: 0931-T64059-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T64059-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2946593-46-8
Target
Others, Kras, Ras
Related Pathways
MAPK, Others
Bioactivity
G12Si-5 is a covalent inhibitor of the K-RasG12S mutant with a Ki value of 26 μM. It binds to the S-IIP structural domain, inhibiting oncogenic signaling and reducing ERK phosphorylation levels in KRAS G12S mutant cells.
Smiles
C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=CC3)C=CC=C4Cl)N5C[C@]6([C@@](CC5)(C(=O)O6)[H])[H])C78N(CCC7)CCC8
Molecular Formula
C31H29ClFN5O3
Molecular Weight
574.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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