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HDAC6/HSP90-IN-2

CAT: 0804-HY-150774Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150774Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and Hsp90, with IC50s of 105.7 and 61 nM, respectively. HDAC6/HSP90-IN-2 can be used for the research of cancer[1].
CAS Number
2803866-22-8
UNSPSC
12352005
Target
Apoptosis; HDAC; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-hsp90-in-2.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C(C)C)C=C(C(N(C)CC2=CC=C(C=C2)C(NO)=O)=O)C(O)=C1
Molecular Formula
C19H22N2O5
Molecular Weight
358.39
References & Citations
[1]Chae HY, et al. Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay. Eur J Med Chem. 2022 Jul 6;240:114582.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC3; HDAC6; HDAC7

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