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Aha1/Hsp90-IN-2

CAT: 0804-HY-179377Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179377Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aha1/Hsp90-IN-2 is a selective inhibitor of the Hsp90/Aha1 interaction, with its IC50 being 1.46 μM. Aha1/Hsp90-IN-2 inhibits the activation of Hsp90 ATPase activity mediated by Aha1 by specifically blocking the binding of Hsp90 to Aha1, thereby reducing tau protein aggregation. Aha1/Hsp90-IN-2 can be used for the study of neurodegenerative diseases, such as Alzheimer's disease[1].
UNSPSC
12352005
Target
HSP; Tau Protein
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=S(C1=CC(C2=CC=CC(OC)=C2)=C(OC)C=C1)(NC3=CC=C(C(F)(F)F)C=C3)=O
Molecular Formula
C21H18F3NO4S
Molecular Weight
437.43
References & Citations
[1]Kevin C, et al. Optimization of Hsp90/Aha1 Small-Molecule Disruptors Via the Evaluation of Amide Bioisosteres. 2025 Nov 7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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