GRK5-IN-3

• Description :

  GRK5-IN-3 is a covalent inhibitor of GRK5 (G Protein-Coupled Receptor Kinase 5) . GRK5-IN-3 shows potent inhibitory effect to GRK5 and GRK6 with IC50s of 0.22 μM and 0.41 μM, respectively[1].

• UNSPSC :

  12352005

• Target :

  G Protein-coupled Receptor Kinase (GRK)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/grk5-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=C(C(OC)=C1)NC2=NC(NC3=C(C(N)=O)C=CC=C3)=C4C=CNC4=N2)C=C

• Molecular Formula :

  C23H21N7O3

• Molecular Weight :

  443.46

• References & Citations :

  [1]Rowlands RA, et al. Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. ACS Med Chem Lett. 2019 Nov 12. 10 (12) :1628-1634.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2410793-22-3]