GRK5-IN-3

CAT:

804-HY-150021

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CAS Number: 2410793-22-3
UNSPSC Description: GRK5-IN-3 is a covalent inhibitor of GRK5 (G Protein-Coupled Receptor Kinase 5). GRK5-IN-3 shows potent inhibitory effect to GRK5 and GRK6 with IC50s of 0.22 μM and 0.41 μM, respectively[1].
Target Antigen: G Protein-coupled Receptor Kinase (GRK)
Type: Reference compound
Related Pathways: GPCR/G Protein
Applications: Neuroscience-Neuromodulation
Field of Research: Others
Assay Protocol: https://www.medchemexpress.com/grk5-in-3.html
Solubility: 10 mM in DMSO
Smiles: O=C(NC1=CC=C(C(OC)=C1)NC2=NC(NC3=C(C(N)=O)C=CC=C3)=C4C=CNC4=N2)C=C
Molecular Weight: 443.46
References & Citations: [1]Rowlands RA, et al. Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. ACS Med Chem Lett. 2019 Nov 12. 10(12):1628-1634.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-150021	GRK5-IN-3
HY-136561-05	GRK5-IN-2
HY-136561-04	GRK5-IN-2
HY-136561-02	GRK5-IN-2
HY-136561-01	GRK5-IN-2
HY-136561-03	GRK5-IN-2
HY-136561-06	GRK5-IN-2
HY-150022	GRK5-IN-4
HY-P703137	GRK5, Human (Sf9, His, GST)
HY-RS05816	GRK5 Human Pre-designed siRNA Set A