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UNP-6457

CAT: 0804-HY-149988Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149988Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM[1].
CAS Number
3072696-60-4
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unp-6457.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1)N2[C@@]3([H])C[C@@](NC([C@@H](NC([C@H](CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CN4C=C(N=N4)C[C@@H](NC3=O)C(N)=O)=O)C(C)C)=O)CC5=CNC6=CC=CC=C56)=O)CC7=CC=CC=C7)=O)=O)C(C)C)=O)CC8=CC(C(F)(F)F)=CC=C8)=O)([H])C2
Molecular Formula
C62H71F3N14O10
Molecular Weight
1229.31
References & Citations
[1]Silvestri AP, et al. DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor. ACS Med Chem Lett. 2023 May 5;14 (6) :820-826.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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