AVI-6451

• Description:

  AVI-6451 is a novel orally effective SARS-CoV-2 Mac1 (IC50 = 28 nM) inhibitor. AVI-6451 can reduce viral load. AVI-6451 can be used for research on viral infections[1].

• UNSPSC:

  12352005

• Target:

  SARS-CoV

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C1OCC(C)(C)N1NC2=C3C(NC4=C3C=C(F)C=C4C5CC5)=NC=N2

• Molecular Formula:

  C18H18FN5O2

• Molecular Weight:

  355.37

• References & Citations:

  [1]Jaishankar P, et al. Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo[J]. bioRxiv, 2025: 2025.10. 11.681833.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported