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IDO1-IN-22

CAT: 0804-HY-149982Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149982Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM) . IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile[1].
CAS Number
2126853-16-3
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ido1-in-22.html
Solubility
10 mM in DMSO
Smiles
CCNC(NC1=NON=C1/C(NC2=CC=C(C(Br)=C2)F)=N/O)=O
Molecular Formula
C12H12BrFN6O3
Molecular Weight
387.16
References & Citations
[1]Ye K, et al. Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors. Eur J Med Chem. 2023 Mar 15;250:115217.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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