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IDO1-IN-32

CAT: 0804-HY-178954Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178954Size:1 Each
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Description
IDO1-IN-32 (Compound 45) is a potent and orally effective IDO1 inhibitor with an IC50 of 10 pM. IDO1-IN-32 exhibits significant anti-proliferative activity against Hela cells. IDO1-IN-32 can significantly inhibit tumor growth in CT26 and LCC transplanted mouse models by activating anti-tumor immunity. IDO1-IN-32 can be used for research on colon cancer and breast cancer[1].
CAS Number
2456309-77-4
Target
Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC=CN1C2=CC(NC(NC3=CC=C(Cl)C=C3F)=O)=C(N(CC(C)C)CC(C)C)C(Cl)=C2)O
Molecular Formula
C26H29Cl2FN4O3
Molecular Weight
535.44
References & Citations
[1]Zou Y, et al. 1- (3,4-Diaminophenyl) -1H-pyrrole-2-carboxylic acids as potent apo-IDO1 inhibitors exhibiting efficacy in syngeneic tumor mouse models. Eur J Med Chem. 2026 Jan 5;301:118222.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO1

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