Analgesic agent-2

CAT: 0804-HY-149944Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149944Size:1 Each
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Description
Analgesic agent-2 is a selective and orally active NaV1.8 Channel inhibitor, with an IC50 of 50.18 nM in HEK293 cells stably expressing human NaV1.8 channel. Analgesic agent-2 has analgesic activity[1].
CAS Number
[2983892-65-3]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/analgesic-agent-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=C(C(N2CCCC(F)(CC2)F)=N1)C(NC3=CC4=C(CNC4=O)C=C3)=O)Cl
Molecular Formula
C21H21ClF2N4O2
Molecular Weight
434.87
References & Citations
[1]Qin H, et al. Discovery of selective NaV1.8 inhibitors based on 5-chloro-2- (4,4-difluoroazepan-1-yl) -6-methyl nicotinamide scaffold for the treatment of pain. Eur J Med Chem. 2023 Jun 5;254:115371.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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