Analgesic agent-2

• Description :

  Analgesic agent-2 is a selective and orally active NaV1.8 Channel inhibitor, with an IC50 of 50.18 nM in HEK293 cells stably expressing human NaV1.8 channel. Analgesic agent-2 has analgesic activity[1].

• CAS Number :

  [2983892-65-3]

• UNSPSC :

  12352005

• Target :

  Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/analgesic-agent-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C(C=C(C(N2CCCC(F)(CC2)F)=N1)C(NC3=CC4=C(CNC4=O)C=C3)=O)Cl

• Molecular Formula :

  C21H21ClF2N4O2

• Molecular Weight :

  434.87

• References & Citations :

  [1]Qin H, et al. Discovery of selective NaV1.8 inhibitors based on 5-chloro-2- (4,4-difluoroazepan-1-yl) -6-methyl nicotinamide scaffold for the treatment of pain. Eur J Med Chem. 2023 Jun 5;254:115371.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported