CDK9-IN-29

• Description :

  CDK9-IN-29 (compound Z11) is a potent CDK9 inhibitor (IC50 = 3.20 nM) with good kinase selectivity. CDK9-IN-29 inhibits cell proliferation and induces apoptosis[1].

• UNSPSC :

  12352005

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cdk9-in-29.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=C(C=C(C=C1)C2=C(C=NC(N3)=N2)F)OCCCCCCOC4=CC3=CC=C4C(NCCN5CCOCC5)=O

• Molecular Formula :

  C29H33F2N5O4

• Molecular Weight :

  553.60

• References & Citations :

  [1]Tizhi Wu, et al. Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2023.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2737262-24-5]