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MMP13-IN-5

CAT: 0804-HY-149378Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149378Size:1 Each
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Description
MMP13-IN-5 (compound 13m) is a potent and selective inhibitor of MMP-2/MMP-13 (IC50=3.6 μM/14.6 μM), involved in osteoarthritis (OA) [1].
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mmp13-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(N/N=C/C1=CC=C(CNC(C2=CC=C(Br)O2)=O)C=C1)CC3=CC=C(C(O)=O)C=C3
Molecular Formula
C22H18BrN3O5
Molecular Weight
484.30
References & Citations
[1]Cuffaro D, et al. Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization. Int J Mol Sci. 2023 Jul 4;24 (13) :11098.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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