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FM04

CAT: 0804-HY-149277-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149277-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM) . FM04 inhibits P-gp in 2 mechanism: (1) FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2) FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp[1].
CAS Number
1807320-40-6
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fm04.html
Purity
99.86
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C2=CC=C(OCCOCCNCC3=CC=CC=C3)C=C2)OC4=C1C=CC=C4
Molecular Formula
C26H25NO4
Molecular Weight
415.48
References & Citations
[1]Liu Z, et al. Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04. J Med Chem. 2023 Apr 25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
MBS5814557FM04

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