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FM04

CAT: 0013-GTR19213786-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213786-03Size:10 mg
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Description
FM04 is a potent, orally bioavailable P-glycoprotein (P-gp) inhibitor with an EC50 of 83 nM. It disrupts the R262-Q1081-Q1118 pocket by interacting with Q1193 and I1115 in NBD2, uncoupling ICL2-NBD2 interactions. This inhibitor is a valuable research tool for investigating multidrug resistance in cancer models, both in vitro and in vivo.
CAS Number
1807320-40-6
Product Name Alternative
Pgp, P-gp (P-glycoprotein)
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.77% (May vary between batches)
Solubility
DMSO:55 mg/mL (132.38 mM)
Smiles
O=C1C=C (OC=2C1=CC=CC2) C3=CC=C (OCCOCCNCC4=CC=CC=C4) C=C3
Molecular Formula
C26H25NO4
Molecular Weight
415.48
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-[4-[2-[2-(Benzylamino)ethoxy]ethoxy]phenyl]chromen-4-one
CAS Number1807320-40-6
PubChem CID118323802
IUPAC Name2-[4-[2-[2-(benzylamino)ethoxy]ethoxy]phenyl]chromen-4-one
Molecular FormulaC26H25NO4
Molecular Weight415.5
XLogP4.4
Topological Polar Surface Area56.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Heavy Atom Count31
Formal Charge0
Complexity578
SMILES
C1=CC=C(C=C1)CNCCOCCOC2=CC=C(C=C2)C3=CC(=O)C4=CC=CC=C4O3
InChI
InChI=1S/C26H25NO4/c28-24-18-26(31-25-9-5-4-8-23(24)25)21-10-12-22(13-11-21)30-17-16-29-15-14-27-19-20-6-2-1-3-7-20/h1-13,18,27H,14-17,19H2
InChIKey
JIFJFNBTQSCGBM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[4-[2-[2-(Benzylamino)ethoxy]ethoxy]phenyl]chromen-4-one
CAS: 1807320-40-6
CID: 118323802
Formula: C26H25NO4
MW: 415.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.5
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass415.17835828
Monoisotopic Mass415.17835828
Topological Polar Surface Area56.8 Ų
Heavy Atom Count31
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5814557FM04

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