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E722-2648

CAT: 0804-HY-148918-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148918-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E722-2648 is a potent β-catenin/BCL9 complex inhibitor. E722-2648 specifically inhibits β-catenin/BCL9 complex formation and Wnt activity. E722-2648 disrupts cholesterol homeostasis via increased cholesterol esterification and lipid droplet accumulation. E722-2648 has antitumor activity[1].
CAS Number
[931963-55-2]
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e722-2648.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(SC2=C3CCCC2)=C3CS1)NCCCN4CCCC(C4)C
Molecular Formula
C21H30N2OS2
Molecular Weight
390.61
References & Citations
[1]Tanton H, et al. A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. Sci Adv. 2022 Apr 29;8 (17) :eabm3108.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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