DO-264

• Description:

  DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.

• Product Name Alternative:

  GCA, GCA-2, (Rac)-GCA

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  MAGL

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/DO-264.html

• Purity:

  99.96

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  S=C(NC1=CC=CN=C1)NC2CCN(C3=NC=CC(OC4=CC=C(OC(F)(F)F)C=C4Cl)=C3Cl)CC2

• Molecular Formula:

  C23H20Cl2F3N5O2S

• Molecular Weight:

  558.40

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ogasawara D, et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14 (12) :1099-1108.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2301866-59-9]