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DBRD 9-A

CAT: 0804-HY-148739-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148739-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family[1].
CAS Number
2170679-42-0
UNSPSC
12352005
Hazard Statement
H301-H360
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbrd-9-a.html
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C(C3=CC(OC)=C(CN(CC(NCCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C)C(OC)=C3)=CN1C)C=CN=C2
Molecular Formula
C42H49N7O8
Molecular Weight
779.88
Precautions
P264-P270-P280-P330-P405-P501
References & Citations
[1]Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56 (21) :5738-5743.|[2]Ye ZHENG, et al. WO2022183056A1. 2022.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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