TP-050

TP-050

• UNSPSC Description: TP-050 is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 μM and 9.6 μM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB). TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission[1].
• Target Antigen: iGluR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/tp-050.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CN(C(C2=CC(CN3N=C(C=C3Cl)C(F)F)=NN12)=O)[C@@H](CC#N)C
• Molecular Weight: 380.78
• References & Citations: [1]Sakurai F, et, al. Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity. Bioorg Med Chem. 2022 Feb 15;56:116576.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported