BI-2081

• Description:

  BI-2081, a chemical probe, is a GPR40 (FFAR1) partial agonist (EC50: 4 nM) . BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2[1].

• UNSPSC:

  12352005

• Target:

  Free Fatty Acid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/bi-2081.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C(C(CC2)=C(C3=C(C=C(C=C3C)OCCC(C)(O)C)C)C=C1)[C@@H]2OC4=CC=C([C@@H](CO5)CC(O)=O)C5=C4

• Molecular Formula:

  C32H35FO6

• Molecular Weight:

  534.62

• References & Citations:

  [1]Governa P, et al. FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity. Bioorg Med Chem Lett. 2021 Jun 1;41:127969.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1458656-71-7]