Glucocerebrosidase-IN-1 (hydrochloride)

CAT:

804-HY-147976A

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CAS Number: 2279945-77-4
UNSPSC Description: Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD)[1].
Target Antigen: Glycosidase
Type: Reference compound
Related Pathways: Metabolic Enzyme/Protease
Applications: Neuroscience-Neuromodulation
Field of Research: Neurological Disease
Assay Protocol: https://www.medchemexpress.com/glucocerebrosidase-in-1-hydrochloride.html
Solubility: 10 mM in DMSO
Smiles: O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O.[H]Cl
Molecular Weight: 281.82
References & Citations: [1]Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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Cat	Name
T60353-5mg	Glucocerebrosidase-IN-1
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T60353-1mg	Glucocerebrosidase-IN-1
T60353-1g	Glucocerebrosidase-IN-1
T60353-10mg	Glucocerebrosidase-IN-1
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