Glucocerebrosidase-IN-1 (hydrochloride)

• UNSPSC Description:

  Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD)[1].

• Target Antigen:

  Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/glucocerebrosidase-in-1-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O.[H]Cl

• Molecular Weight:

  281.82

• References & Citations:

  [1]Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2279945-77-4