Antiangiogenic agent 2

• Description :

  Antiangiogenic agent 2 (compound 3b) is a potent thymidine phosphorylase inhibitor, with an IC50 of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity[1].

• UNSPSC :

  12352005

• Target :

  Nucleoside Antimetabolite/Analog

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/antiangiogenic-agent-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCN(C(CC5=CC=CC=C5)=O)CC4)=C3)C1=O)OC

• Molecular Formula :

  C26H26FN3O4

• Molecular Weight :

  463.50

• References & Citations :

  [1]Shahzad SA, et al. Synthesis, evaluation of thymidine phosphorylase and angiogenic inhibitory potential of ciprofloxacin analogues: Repositioning of ciprofloxacin from antibiotic to future anticancer drugs. Bioorg Chem. 2020 Jul;100:103876.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2422149-84-4]