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PI3K-IN-34

CAT: 0804-HY-147899Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147899Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research[1].
CAS Number
2458163-94-3
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-in-34.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N2CCOCC2)N=C(N/N=C/C3=CC=CC(O)=C3)N=C1C4=CC=C(OC)C=C4
Molecular Formula
C23H22N6O3
Molecular Weight
430.46
References & Citations
[1]Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kδ

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