Angiogenesis inhibitor 3

CAT:

804-HY-147891

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CAS Number: 2507759-39-7
UNSPSC Description: Angiogenesis inhibitor 3 (compound 8) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 3 inhibits the proliferation of HUVEC and HCT-15 cells, with IC50 values of 1.00 and 0.71 μM. Angiogenesis inhibitor 3 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 3 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 3 inhibits the angiogenesis in zebrafish embryos[1].
Target Antigen: Apoptosis
Type: Reference compound
Related Pathways: Apoptosis
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/angiogenesis-inhibitor-3.html
Solubility: 10 mM in DMSO
Smiles: O=C(C1=CC=CC=C1)OC2=C3C4=C(C(Br)=C2OC)CCN(C)[C@@]4([H])CC5=C(C=C(C(OC6=CC=C(C[C@@]7([H])C8=CC(O3)=C(C=C8CCN7C)OC)C=C6)=C5)OC)[N+]([O-])=O
Molecular Weight: 836.72
References & Citations: [1]Zhang RH, et al. Discovery of tetrandrine derivatives as tumor migration, invasion and angiogenesis inhibitors. Bioorg Chem. 2020 Aug;101:104025.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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