UIAA-II-232

• Description:

  UIAA-II-232 (compound 19b) is a potent DNA gyrase catalytic inhibitor with an IC50 value of 3.5 µM[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/uiaa-ii-232.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (C1=C2N (N=C1) C (N (CC) C3=C2C=C (F) C (N4C[C@H] (CN) CC4) =C3) =O) OCC

• Molecular Formula:

  C20H24FN5O3

• Molecular Weight:

  401.43

• References & Citations:

  [1]Aguirre AL, et al. Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase. Bioorg Med Chem. 2020 May 15;28 (10) :115439.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2428407-03-6