TRPC3/6-IN-1

• CAS Number:

  736945-96-3

• UNSPSC Description:

  TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].

• Target Antigen:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/trpc3-6-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(NC2=NC(C(N3CCC4=C(C3)C=CC=C4)=O)=CS2)C=C1

• Molecular Weight:

  365.45

• References & Citations:

  [1]David G Washburn, et al. The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported