PI3K-IN-37

• Description:

  PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  MTOR; PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/pi3k-in-37.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C2=C(N1C)C=NC3=CC=C(C4=CC(OC(C)C)=C(C)N=C4)C=C23)C5=CN(C)N=C5C

• Molecular Formula:

  C25H26N6O2

• Molecular Weight:

  442.51

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]FURET Pascal, et al. 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES. WO2010139731A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MTOR; PI3Kα; PI3Kβ; PI3Kδ

• CAS Number:

  [1257547-40-2]