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HPGDS inhibitor 3

CAT: 0804-HY-146662Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146662Size:1 Each
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Description
HPGDS inhibitor 3 is an orally active and highly potent peripherally restricted hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 value of 9.4 nM and EC50 of 42 nM, respectively. HPGDS inhibitor 3 exhibits good selectivity, good pharmacokinetic parameters in mouse, rat, and dog, and no CNS toxicity. HPGDS inhibitor 3 has anti-inflammatory activity[1].
CAS Number
2255311-93-2
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpgds-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
CC(O)([C@H]1CC[C@@H](CC1)NC(C2=CC3=CC=C(N=C3N=C2)C4CC4)=O)C
Molecular Formula
C21H27N3O2
Molecular Weight
353.46
References & Citations
[1]Cadilla R, Deaton DN, Do Y, et al. The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure. Bioorg Med Chem. 2020;28 (23) :115791.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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