Products for Research Use Only
RegisterLogin

RAGE/SERT-IN-1

CAT: 0804-HY-146619Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-146619Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
RAGE/SERT-IN-1 is a potent and orally active advanced glycation end products (RAGE) and serotonin transporter (SERT) inhibitor with IC50s of 8.26 μM and 31.09 nM, respectively. RAGE/SERT-IN-1 exhibits significant neuroprotective effect against Aβ25-35-induced neuronal damage and alleviates depressive behavior of mice. RAGE/SERT-IN-1 can be used for researching the comorbidity of Alzheimer's disease and depression[1].
CAS Number
2766739-35-7
UNSPSC
12352005
Target
Amyloid-β; Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rage-sert-in-1.html
Solubility
10 mM in DMSO
Smiles
CCCCC1=C(N=C(S1)C2CCN(CC2)CCCCC3=CN(C4=C3C=C(C=C4)C#N)C)C5=CC=C(C=C5)OC6=CC=C(C=C6)Cl
Molecular Formula
C38H41ClN4OS
Molecular Weight
637.28
References & Citations
[1]Zhang C, Wang L, Xu Y, et al. Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression. Eur J Med Chem. 2022;236:114347.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-168021MAO-A/SERT-IN-1
HY-178907SERT/5-HT-IN-1
HY-160655SERT-IN-3
HY-148565-01SERT-IN-2
HY-147329-01RAGE 229
HY-P11222Tat-SERT-15C
HY-P703209SERT, Human (HEK293)
HY-P81086-01RAGE Antibody (Rabbit)
HY-P2268-01RAGE antagonist peptide
HY-P703210SERT, Human (HEK293, Strep)

Alternative Products

CatalogName
T72824-01RAGE/SERT-IN-1
T200256-01MAO-A/SERT-IN-1
GTR19273482-01SERT/5-HT-IN-1
BA8548-10SERT-IN-2
E51A11554SERT Antibody
T87382-01SERT-IN-3
sc-4527 WBRAGE (1-300)
sc-74473RAGE (E-1)
212999-01RAGE (Receptor for Advanced Glycosylation End Products, MOK, RAGE, RAGE-1, RAGE1) discontinued
MBS6434899-01RAGE (Receptor for Advanced Glycosylation End Products, MOK, RAGE, RAGE-1, RAGE1) (PE)

Popular Products