RAGE 229

• UNSPSC Description:

  RAGE 229 is an orally active ctRAGE-DIAPH1 inhibitor. RAGE 229 can inhibit the intracellular RAGE signaling by inhibiting the interaction between the cytoplasmic tail of RAGE(ctRAGE) and Diaphanous-1(DIAPH1)[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/rage-229.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)

• Smiles:

  CC(NC1=CC=C(C2=NC3=CC(C#N)=CC=C3C(CN4CCOCC4)=C2)C=C1)=O

• Molecular Weight:

  386.45

• References & Citations:

  [1]Michaele B Manigrasso, et al. Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Sci Transl Med. 2021 Nov 24;13(621):eabf7084.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2143072-85-7