Anti-inflammatory agent 20

• Description :

  Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of NF-κB and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation[1].

• UNSPSC :

  12352005

• Target :

  COX; NF-κB; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/anti-inflammatory-agent-20.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [H][C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(C(C)([C@H](CC[C@@]4([C@]3(C[C@H]2O)[H])C)OC(CNC(CNC(OC(C)(C)C)=O)=O)=O)C)[H])C)C)[C@@]5(CC[C@@H](O5)C(C)(O)C)C

• Molecular Formula :

  C39H66N2O8

• Molecular Weight :

  690.95

• References & Citations :

  [1]Yang G, et al. Design, synthesis and anti-inflammatory activity of 3-amino acid derivatives of ocotillol-type sapogenins. Eur J Med Chem. 2020 Sep 15;202:112507.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2; NF-κB; TNFRSF5/CD40

• CAS Number :

  [2127403-65-8]