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Anti-inflammatory agent 20

CAT: 0804-HY-146419Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146419Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of NF-κB and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation[1].
CAS Number
2127403-65-8
UNSPSC
12352005
Target
COX; NF-κB; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-20.html
Solubility
10 mM in DMSO
Smiles
[H][C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(C(C)([C@H](CC[C@@]4([C@]3(C[C@H]2O)[H])C)OC(CNC(CNC(OC(C)(C)C)=O)=O)=O)C)[H])C)C)[C@@]5(CC[C@@H](O5)C(C)(O)C)C
Molecular Formula
C39H66N2O8
Molecular Weight
690.95
References & Citations
[1]Yang G, et al. Design, synthesis and anti-inflammatory activity of 3-amino acid derivatives of ocotillol-type sapogenins. Eur J Med Chem. 2020 Sep 15;202:112507.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; NF-κB; TNFRSF5/CD40

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