MIF-IN-6

MIF-IN-6

• CAS Number: 2582758-61-8
• UNSPSC Description: MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC50 of 1.4 μM and a Ki value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells[1].
• Target Antigen: Macrophage migration inhibitory factor (MIF)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer; Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mif-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC2=CC(Cl)=CC=C2N1)NCC3=CN(N=N3)C4=CC(F)=C(C=C4)O
• Molecular Weight: 385.78
• References & Citations: [1]Xiao Z, Fokkens M, Chen D, et al. Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF). Eur J Med Chem. 2020;186:111849.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported