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MIF-IN-6

CAT: 0804-HY-146319Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146319Size:1 Each
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Description
MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC50 of 1.4 μM and a Ki value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells[1].
CAS Number
2582758-61-8
UNSPSC
12352005
Target
Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mif-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=CC(Cl)=CC=C2N1)NCC3=CN(N=N3)C4=CC(F)=C(C=C4)O
Molecular Formula
C18H13ClFN5O2
Molecular Weight
385.78
References & Citations
[1]Xiao Z, Fokkens M, Chen D, et al. Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF) . Eur J Med Chem. 2020;186:111849.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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