Tubulin/MMP-IN-1

• UNSPSC Description:

  Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway[1].

• Target Antigen:

  Microtubule/Tubulin; MMP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tubulin-mmp-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCOP(OCC)(C(C1=CC=CC=C1C)NC2=CC=C(C=C2)CC(OC3=CC(/C=C\C4=CC(OC)=C(C(OC)=C4)OC)=CC=C3OC)=O)=O

• Molecular Weight:

  689.73

• References & Citations:

  [1]Yang L, et al. Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases [published online ahead of print, 2022 May 5]. Eur J Med Chem. 2022;238:114439.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported