β-S-ARCA

• Description :

  β-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines[1].

• CAS Number :

  [1093268-63-3]

• Product Name Alternative :

  3'-O-Me-m7G (5') ppp (5') G

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Oligonucleotides

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/β-s-arca.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)OP(OP(OC[C@@H]4[C@@H](O)[C@@H](OC)[C@H](N5C(NC(N)=N6)=C([N+](C)=C5)C6=O)O4)([O-])=O)(S)=O

• Molecular Formula :

  C22H31N10O17P3S

• Molecular Weight :

  832.52

• References & Citations :

  [1]Warminski M, et al. Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 Feb 19;16 (2) :334-343.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported