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D4R antagonist-1

CAT: 0804-HY-145905Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145905Size:1 Each
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Description
D4R antagonist-1 is a potent and selective D4R antagonist with an IC50 of 6.87 μM. D4R antagonist-1 has the potential for the research of Parkinson’s disease[1].
CAS Number
2846077-19-6
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d4r-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1F)CN2CCC[C@@H](C2)OCC3=CC(C)=C(C=C3)F
Molecular Formula
C21H25F2NO2
Molecular Weight
361.43
References & Citations
[1]Tolentino KT, et al. Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists. Bioorg Med Chem Lett. 2022; 61:128615.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor

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