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JPS004

CAT: 0804-HY-176904Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176904Size:1 Each
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Description
JPS004 is a HDAC1-3 PROTAC degrader. JPS004 can induce degradation of HDAC1-3 and induce histone acetylation. JPS004 can induce cancer cells apoptosis. JPS004 can be used for the research of cancer[1]. (Structure Note: Pink: HDAC1-3 ligand ; Blue: VHL ligand (HY-125845) ; HDAC1-3 ligand-Linker: (HY-176905) )
CAS Number
2559747-12-3
UNSPSC
12352005
Target
Apoptosis; HDAC; PROTACs
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC(C=CC=C1)=C1NC(C(C=C2)=CC=C2NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(NCC4=CC=C(C5=C(N=CS5)C)C=C4)=O)=O)=O)=O)=O
Molecular Formula
C47H61N7O6S
Molecular Weight
852.10
References & Citations
[1]India M. Baker, et al. Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs) . Biochemistry 2023, 62, 3, 645–656
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; von Hippel-Lindau (VHL)

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