NH2-PEG5-OH

• Description :

  NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nh2-peg5-oh.html

• Purity :

  99.82

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OCCOCCOCCOCCOCCN

• Molecular Formula :

  C10H23NO5

• Molecular Weight :

  237.29

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.|[2]Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Non-cleavable Linker; PEG Linkers

• CAS Number :

  [34188-11-9]