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Azido-PEG2-VHL

CAT: 0804-HY-145715Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145715Size:1 Each
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Description
Azido-PEG2-VHL is a multikinase degrader which can be used in the synthesis of PROTACs[1]. Azido-PEG2-VHL is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
2597167-22-9
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg2-vhl.html
Solubility
10 mM in DMSO
Smiles
[N-]=[N+]=NCCOCCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O
Molecular Formula
C29H41N7O6S
Molecular Weight
615.74
References & Citations
[1]STATSYUK A, et, al. Multikinase degraders. WO2021021797A1.|[2]Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15 (9) :2316-2323.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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