Donepezil Hydrochloride

CAT: 0127-OR1029881-01Size: 250 mgDry Ice: NoHazardous: No

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CAT#:0127-OR1029881-01Size:250 mg

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CAS Number

110119-84-1

Synonyms

2-[ (1-benzylpiperidin-4-yl) methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; hydrochloride

Purity

98%

Smiles

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

Chemical Information

Donepezil Hydrochloride

Donepezil Hydrochloride is the hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases.

CAS Number	110119-84-1
PubChem CID	5741
IUPAC Name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
Molecular Formula	C24H30ClNO3
Molecular Weight	416.0
Topological Polar Surface Area	38.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	29
Formal Charge	0
Complexity	510

SMILES

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

InChI

InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

InChIKey

XWAIAVWHZJNZQQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 110119-84-1

CID: 5741

Formula: C24H30ClNO3

MW: 416.0

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	416.0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	415.1914215
Monoisotopic Mass	415.1914215
Topological Polar Surface Area	38.8 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	510
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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T6478-01	Donepezil Hydrochloride
HY-B0034-01	Donepezil (Hydrochloride)
HY-B0034S1-01	Donepezil-d4 (hydrochloride)
TMIH-0200-01	Donepezil-d7 Hydrochloride
sc-218266	Donepezil-13C3 Hydrochloride
A10330-25	Donepezil hydrochloride 25mg
GTR19191812-01	Deoxy Donepezil (hydrochloride)
AR-D02658-01	Deoxy Donepezil Hydrochloride

Donepezil Hydrochloride

Chemical Information

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