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SLEC-11

CAT: 0804-HY-145268Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145268Size:1 Each
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Description
SLEC-11 is a CDH1/E-cadherin modulator that potently inhibits cell death in E-cadherin-deficient cells (EC50=8.2 μM) . SLEC-11 can be used to study potential synthetic lethal therapies for gastric cancer[1].
CAS Number
863761-17-5
UNSPSC
12352005
Target
Cadherin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/slec-11.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(CNC2=CC(C)=NC3=C2C=C(OC)C=C3)C=C1
Molecular Formula
C18H17FN2O
Molecular Weight
296.34
References & Citations
[1]Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64 (24) :18114-18142.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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