SLEC-11

• Description :

  SLEC-11 is a CDH1/E-cadherin modulator that potently inhibits cell death in E-cadherin-deficient cells (EC50=8.2 μM) . SLEC-11 can be used to study potential synthetic lethal therapies for gastric cancer[1].

• CAS Number :

  [863761-17-5]

• UNSPSC :

  12352005

• Target :

  Cadherin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/slec-11.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C(CNC2=CC(C)=NC3=C2C=C(OC)C=C3)C=C1

• Molecular Formula :

  C18H17FN2O

• Molecular Weight :

  296.34

• References & Citations :

  [1]Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64 (24) :18114-18142.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported