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E3 ligase Ligand 22

CAT: 0804-HY-144983Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144983Size:1 Each
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Description
E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway[1].
CAS Number
2377849-57-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-22.html
Solubility
10 mM in DMSO
Smiles
CC1(CCC1)CN2CCC(CC2)N3C=C(C=N3)CNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O
Molecular Formula
C28H34N6O4
Molecular Weight
518.61
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Gesine Kerstin VEITS, et al. Cereblon binders for the degradation of ikaros. WO2019191112A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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