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Anti-inflammatory agent 11

CAT: 0804-HY-144727Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144727Size:1 Each
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Description
Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].
CAS Number
63932-07-0
UNSPSC
12352005
Target
Bacterial; TNF Receptor
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-11.html
Solubility
10 mM in DMSO
Smiles
[H]N(C(N(NC(C1=CC=NC=C1)=O)[H])=S)CC2=CC=CC=C2
Molecular Formula
C14H14N4OS
Molecular Weight
286.35
References & Citations
[1]Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF5/CD40

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