diSPhMC-Asn-Pro-Val-PABC-MMAE

• UNSPSC Description:

  diSPhMC-Asn-Pro-Val-PABC-MMAE (compound 9) is a potent ADC Linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

• Target Antigen:

  Drug-Linker Conjugates for ADC

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/disphmc-asn-pro-val-pabc-mmae.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OCC1=CC=C(C=C1)NC([C@@H](NC([C@H]2N(CCC2)C([C@@H](NC(CCCCCN3C(C(SC4=CC=CC=C4)=C(C3=O)SC5=CC=CC=C5)=O)=O)CC(N)=O)=O)=O)C(C)C)=O)N([C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@H]([C@H](OC)CC(N6CCC[C@]6([C@@H]([C@H](C(N[C@@H]([C@@H](O)C7=CC=CC=C7)C)=O)C)OC)[H])=O)[C@H](CC)C)=O)=O)C

• Molecular Weight:

  1587.00

• References & Citations:

  [1]Mohamed Amar IA, et al. Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate. Eur J Med Chem. 2022 Feb 5;229:114063.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2893871-68-4