Aurora kinase inhibitor-3
CAT:
804-HY-112373-01
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Aurora kinase inhibitor-3
- CAS Number: 879127-16-9
- UNSPSC Description: Aurora kinase inhibitor-3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket[1].
- Target Antigen: Aurora Kinase
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/aurora-kinase-inhibitor-3.html
- Purity: 99.05
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2
- Molecular Weight: 413.40
- References & Citations: [1]Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported