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IDO1-IN-13

CAT: 0804-HY-144273Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144273Size:1 Each
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Description
IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC50 of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC50= 30 nM) . IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues[1].
CAS Number
3037206-99-5
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ido1-in-13.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(C=C1)NC(NCC2=CSC(/C(NC3=CC=CC(Br)=C3)=N/O)=C2)=O
Molecular Formula
C20H16BrN5O2S
Molecular Weight
470.34
References & Citations
[1]Yeh TK, et al. Discovery and development of a novel N- (3-bromophenyl) -{[ (phenylcarbamoyl) amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design. Eur J Med Chem. 2022;229:114043.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO1

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