PI3Kδ-IN-10

PI3Kδ-IN-10

• CAS Number: 2409725-49-9
• UNSPSC Description: PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC50 of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models[1].
• Target Antigen: Akt; Apoptosis; PI3K
• Type: Reference compound
• Related Pathways: Apoptosis;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kδ-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=C(N[C@H](C2=NN(C3=CC=CN=C3)C4=C2C=CC(Cl)=C4)C)N=C(N)N=C1N
• Molecular Weight: 405.84
• References & Citations: [1]Qi J, Wang W, Tang Y, et al. Discovery of Novel Indazoles as Potent and Selective PI3Kδ Inhibitors with High Efficacy for Treatment of Hepatocellular Carcinoma. J Med Chem. 2022;65(5):3849-3865.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported