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HGGPPS-IN-1

CAT: 0804-HY-144128Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144128Size:1 Each
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Description
HGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS) . hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) . hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
CAS Number
1429012-38-3
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hggpps-in-1.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(C(P(O)(O)=O)NC1=C2C=CSC2=NC(C3=CC=CC=C3)=N1)O
Molecular Formula
C13H13N3O6P2S
Molecular Weight
401.27
References & Citations
[1]Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65 (3) :2471-2496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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