Pan-Trk-IN-2

• UNSPSC Description:

  Compound cpd-1 is a small molecule Trks inhibitor with good antitumor activity[1].

• Target Antigen:

  Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pan-trk-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(NC(N=CN=C3N4)=C3OC(C)(C)C4=O)C=C2

• Molecular Weight:

  506.86

• References & Citations:

  [1]Pan S,et al. Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants. J Med Chem. 2022 Feb 10;65(3):2035-2058.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2583778-77-0