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Pan-RAS-IN-2

CAT: 0804-HY-158409-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158409-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects[1].
CAS Number
3034673-92-9
UNSPSC
12352005
Target
Cyclophilin; Molecular Glues; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-ras-in-2.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OCC(C)(CC2=[C@@]([C@@]3=C([C@H](C)OC)N=CC(N4CCN(C)CC4)=C3)N(CC)C5=CC=C(C6=CSC(C[C@H](NC([C@H]7[C@H](C)[C@@H]7C)=O)C(N8N[C@H]1C9CC8C9)=O)=N6)C=C25)C
Molecular Formula
C46H60N8O5S
Molecular Weight
837.08
References & Citations
[1]Y Zhang, et al. Macrocyclic derivative and use thereof. WO2024067857A1. 2023-09-28
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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