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Indomethacin-d4

CAT: 0804-HY-14397SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14397SSize:1 mg
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Description
Indomethacin-d4 (Indometacin-d4) is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].
CAS Number
87377-08-0
Product Name Alternative
Indometacin-d4
UNSPSC
12352005
Hazard Statement
H300, H317, H360
Target
Autophagy; COX; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Immunology/Inflammation; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Purity
99.78
Solubility
10 mM in DMSO
Smiles
O=C(O)CC1=C(C)N(C(C2=C([2H])C([2H])=C(Cl)C([2H])=C2[2H])=O)C3=C1C=C(OC)C=C3
Molecular Formula
C19H12D4ClNO4
Molecular Weight
361.81
Precautions
H300, H317, H360
References & Citations
[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121 (1) :105-17.|[2]Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8 (1) :3593.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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Alternative Products

CatalogName
T11655Indomethacin-D4
AR-I03674-01Indomethacin (Indometacin) EP Impurity H-d4 (Indomethacin Methyl Ester-d4)
CS-T-98645Indomethacin-d4 Methyl Ester
CS-O-46724Indomethacin ethyl ester D4
TRC-D291802-10MGO-Desmethyl Indomethacin-d4
CS-T-52226O-Desmethyl Indomethacin D4
TRC-E193602-100MGIndomethacin-D4 2-Ethylhexyl Ester
TRC-I193602-25MGIndomethacin (4-Chlorobrnzoyl-D4) I-Methyl Ester
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