Indomethacin-d4

Indomethacin-d4

• CAS Number: 87377-08-0
• UNSPSC Description: Indomethacin-d4 is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].
• Target Antigen: Autophagy; COX; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;Immunology/Inflammation;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Inflammation/Immunology
• Purity: 99.78
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)CC1=C(C)N(C(C2=C([2H])C([2H])=C(Cl)C([2H])=C2[2H])=O)C3=C1C=C(OC)C=C3
• Molecular Weight: 361.81
• References & Citations: [1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.|[2]Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8(1):3593.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported